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CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand. 4-1BB/TNFRSF9/CD137: Products.

On T and NK cells, CD137 is expressed following activation and, if ligated by its natural ligand (CD137L), conveys polyubiquitination‐mediated signals via TNF receptor associated factor 2 that inhibit apoptosis, while enhancing proliferation and We identified 4 distinct homozygous mutations in TNFRSF9 encoding the tumor necrosis factor receptor superfamily member CD137/4-1BB, leading to reduced, or loss of, protein expression. Lymphocytic responses crucial for immune surveillance, including activation, proliferation, and differentiation, were impaired. CD137-Ligand, also known as 4-1BB-Ligand or TNFRSF9-Ligand, is the natural agonist of the CD137 receptor, and a member of the TNF superfamily. CD137-Ligand is expressed on antigen presenting cells, such as dendritic cells, B cells, and macrophages.

Expression of CD137 4-1BB on Human Follicular Dendritic Cells

CD137 (ILA/4-1BB), a member of the TNF receptor family, was shown previously to inhibit proliferation and to induce apoptosis in T lymphocytes. In this study, we identify CD137 as a novel and potent monocyte activation factor. CD137 (4-1BB, TNF-receptor superfamily 9) is a surface glycoprotein of the TNFR family which can be induced on a variety of leukocyte subsets.

CD137 Pathway: Immunology and Diseases - Medicinsk forskning

Signaling via 4-1BB upregulates survival genes, enhances cell division, induces cytokine production, and prevents activation-induced cell death in T cells.

Co-stimulation through CD137 enhances T lymphocyte activation and may enable rejection of tumors in vivo. CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.
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CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation th CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily.

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Co-stimulation through CD137 enhances T lymphocyte activation and may enable rejection of tumors in vivo. CD137 is a 39 kD transmembrane protein also known as 4-1BB.
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CD28. CTLA-4. PD-1. PD-L1. 4-1BB. Ipilimumab. (Phase III).

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4-1BB/CD137/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells (2-5). The ligand 4-1BBL/CD137L/TNFSF9 on antigen presenting cells binds to 4-1BB/CD137/TNFRSF9 and costimulates the activation of T cells (5). The soluble form of 4-1BB circulates at elevated levels in the serum of rheumatoid arthritis. 4-1BB, also known as CD137, ILA and TNFRSF9, is a single-pass type I transmembrane glycoprotein of the TNF receptor superfamily (TNFRSF). 41BB is expressed as a disulfidelinked homodimer on activated T cells. 4-1BB (CD137) is a 39 kD transmembrane protein that is a member of the tumor necrosis factor (TNF) receptor family and is a co-stimulatory molecule that plays a role in T-cell-mediated proliferative response. About InVivoPlus anti-mouse 4-1BB (CD137).

Description. Recombinant HEK293 cell line expressing a full length human CD137 (4-1BB) (NM_001561). The NF-ĸB luciferase reporter construct is stably integrated into the genome. The firefly luciferase gene is controlled by 4 copies of NF-κB response element located upstream of the TATA promoter. 4-1BB (also known as CD137) Inhibitor. CD137.